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Ligand · OT4

OT4 · 7-[3-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine

OT4, 7-[3-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine (C18 H19 N3, 277.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most…

Component
OT4
Formula
C18 H19 N3
Class
ligand
Structures
4
PDB entries
2

Binding sites

OT4 in 4 structures; the first of them:

  • 6PMY · Structure of rat neuronal nitric oxide synthase heme domain in complex with… · OT4 A803 · binds PRO565, VAL567, PHE584, GLY586, TRP587, TYR588, GLU592, TYR706
  • 6PND · Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in… · OT4 A803 · binds PRO570, VAL572, PHE589, SER590, GLY591, TRP592, TYR593, GLU597 and 2 more
  • 6PMY · Structure of rat neuronal nitric oxide synthase heme domain in complex with… · OT4 A803 · binds PRO565, VAL567, PHE584, GLY586, TRP587, TYR588, GLU592, TYR706
  • 6PND · Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in… · OT4 A803 · binds PRO570, VAL572, PHE589, SER590, GLY591, TRP592, TYR593, GLU597 and 2 more

Residues it binds most

TYR 8, TRP 8, GLU 8, GLY 8, PHE 8, PRO 8, VAL 8, SER 4, MET 2 (residue and the binding sites it lines).

Found with

  • H4B · 5,6,7,8-tetrahydrobiopterin
  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • ACT · Acetate ion

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