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Ligand · OP8

OP8 · (1aR,3R,5S,6R,7S,9R,10R,17aS,20S,21R,22S,25R,25aR)-25-Ethyl-10,22-dihydroxy-20-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-5,7-dimethoxy-1a,3,9,21-tetramethyloctadecahydro-2H-6,10-epoxyoxireno[p]pyrido[2,1-c][1,4]oxazacyclotricosine-11,12,18,24(1aH,14H)-tetrone

OP8, (1aR,3R,5S,6R,7S,9R,10R,17aS,20S,21R,22S,25R,25aR)-25-Ethyl-10,22-dihydroxy-20-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-5,7-dimethoxy-1a,3,9,21-tetramethyloctadecahydro-2H-6,10-epoxyoxireno[p]pyrido[2,1-c][1,4]…

Component
OP8
Formula
C43 H69 N O13
Class
ligand
Structures
2
PDB entries
1

Binding sites

OP8 in 2 structures; the first of them:

  • 6YF1 · FKBP12 in complex with the BMP potentiator compound 8 at 1.12A resolution · OP8 A201 · binds TYR26, PHE36, ASP37, ARG42, PHE46, GLU54, VAL55, ILE56 and 7 more
  • 6YF1 · FKBP12 in complex with the bmp potentiator compound 8 at 1.12A resolution · OP8 A201 · binds TYR26, PHE36, ASP37, ARG42, PHE46, GLU54, VAL55, ILE56 and 5 more

Residues it binds most

PHE 2, ILE 2, TYR 2, ALA 2, ARG 2, ASP 2, GLU 2, TRP 2, VAL 2, HIS 1 (residue and the binding sites it lines).

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