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Ligand · OGH

OGH · 4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine

OGH, 4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine (C21 H21 F N8 O, 420.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component
OGH
Formula
C21 H21 F N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

OGH in 2 structures; the first of them:

  • 6Y8N · Mycobacterium thermoresistibile GyrB21 in complex with Redx03863 · OGH A401 · binds VAL49, ASN52, ALA53, GLU56, VAL77, SER78, ASP79, ARG82 and 14 more
  • 6Y8N · Mycobacterium thermoresistibile GYRB21 in complex with REDX03863 · OGH A401 · binds VAL49, ASN52, ALA53, GLU56, VAL77, SER78, ASP79, ARG82 and 11 more

Residues it binds most

VAL 4, GLY 4, ARG 4, MET 4, ALA 4, ASN 4, ASP 4, GLU 4, ILE 4, PRO 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • EDO · 1,2-ethanediol

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