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Ligand · NL4

NL4 · 3-((4-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)-1H-pyrazol-1-yl)methyl)-N,N-dimethylbenzamide

NL4, 3-((4-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)-1H-pyrazol-1-yl)methyl)-N,N-dimethylbenzamide (C24 H23 Cl N8 O, 474.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
NL4
Formula
C24 H23 Cl N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

NL4 in 2 structures; the first of them:

  • 5AAF · Aurora A kinase bound to an imidazopyridine inhibitor (14a) · NL4 A1001 · binds ARG137, LEU139, GLY140, LYS141, VAL147, ALA160, LEU194, LEU210 and 10 more
  • 5AAF · Aurora a kinase bound to an imidazopyridine inhibitor (14A) · NL4 A1001 · binds ARG137, LEU139, GLY140, LYS141, VAL147, ALA160, LEU194, LEU210 and 10 more

Residues it binds most

LEU 2, ALA 2, ARG 2, GLU 2, GLY 2, TYR 2, LYS 2, PRO 2, THR 2, VAL 2 (residue and the binding sites it lines).

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