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Ligand · NKF

NKF · 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl) pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile

NKF, 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl) pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile (C22 H24 N6 O, 388.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
NKF
Formula
C22 H24 N6 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

NKF in 2 structures; the first of them:

  • 7UKR · Crystal Structure of SOS1 with MRTX0902, a Potent and Selective Inhibitor of the… · NKF A1101 · binds MET878, ASN879, TYR884, PHE890, LYS898, LEU901, GLU902, HIS905
  • 7UKR · Crystal structure of SOS1 with MRTX0902, a potent and selective inhibitor of the… · NKF A1101 · binds MET878, ASN879, TYR884, PHE890, LYS898, LEU901, GLU902, HIS905

Residues it binds most

ASN 4, GLU 4, HIS 4, LEU 4, LYS 4, MET 4, PHE 4, TYR 4, VAL 1 (residue and the binding sites it lines).

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