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Ligand · N7Q

N7Q · ~{N}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy) phenyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide

N7Q, ~{N}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy) phenyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide (C29 H27 Cl N6 O4, 559.0 g/mol), in the MolNFT structures on GenesisL1: bound in 1 record (1…

Component
N7Q
Formula
C29 H27 Cl N6 O4
Class
ligand
Structures
1
PDB entries
1

Binding sites

N7Q in 1 structure; the first of them:

  • 6TFV · Crystal structure of EGFR T790M/V948R in complex with covalent pyrrolopyrimidine 18B · N7Q A1101 · binds LEU718, GLY719, SER720, PHE723, VAL726, ALA743, LYS745, MET766 and 15 more

Residues it binds most

LEU 2, MET 2, ASP 2, CYS 2, GLY 2, PHE 2, ALA 2, ARG 2, GLN 2, LYS 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol

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