Ligand · N0J

N0J · (4s,7ar,9ar,10s,11e,15r)-6'-chloro-15-ethyl-10-hydroxy-3',4',7A,8,9,9A,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-F][1,2, 7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16, 18(7H,17H)-trione

N0J, (4s,7ar,9ar,10s,11e,15r)-6'-chloro-15-ethyl-10-hydroxy-3',4',7A,8,9,9A,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-F][1,2, 7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16…

Component: N0J
Formula: C32 H39 Cl N2 O5 S
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

N0J in 2 structures; the first of them:

6OQB · Co-crystal structure of Mcl1 with inhibitor 10 · N0J A401 · binds HIS224, ALA227, PHE228, MET231, LEU235, LEU246, VAL249, MET250 and 11 more
6OQB · Co-crystal structure of MCL1 with inhibitor 10 · N0J A401 · binds HIS224, ALA227, PHE228, VAL249, MET250, VAL253, PHE254, GLY262 and 7 more

Residues it binds most

LEU 2, PHE 2, VAL 2, GLY 2, MET 2, ALA 2, ARG 2, HIS 2, ILE 2, THR 2 (residue and the binding sites it lines).

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