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Ligand · MTZ

MTZ · 4-methyl-5-{(2E)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amine

MTZ, 4-methyl-5-{(2E)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amine (C18 H20 N6 O S, 368.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
MTZ
Formula
C18 H20 N6 O S
Class
ligand
Structures
2
PDB entries
1

Binding sites

MTZ in 2 structures; the first of them:

  • 2UUE · REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors · MTZ A1297 · binds ILE10, GLY13, VAL18, ALA31, LYS33, GLU51, VAL64, PHE80 and 9 more
  • 2UUE · Replace: a strategy for iterative design of cyclin binding groove inhibitors · MTZ A1297 · binds ILE10, GLY13, VAL18, ALA31, LYS33, GLU51, VAL64, PHE80 and 9 more

Residues it binds most

GLU 4, LEU 4, LYS 4, PHE 4, VAL 4, ASP 4, ALA 4, GLN 4, GLY 4, HIS 4 (residue and the binding sites it lines).

Found with

  • GVC · 1-(3,5-dichlorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxylic acid
  • NH2 · Amino group

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