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Ligand · MPJ

MPJ · (1-amino-3-methylsulfanyl-propyl)-phosphinic acid

MPJ, (1-amino-3-methylsulfanyl-propyl)-phosphinic acid (C4 H12 N O2 P S, 169.2 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most…

Component
MPJ
Formula
C4 H12 N O2 P S
Class
ligand
Structures
6
PDB entries
3

Binding sites

MPJ in 6 structures; the first of them:

  • 1C24 · E. COLI methionine aminopeptidase: methionine phosphinate complex · MPJ A300 · binds CYS59, TYR62, TYR65, CYS70, HIS79, ASP97, THR99, ASP108 and 6 more
  • 1PFU · Methionyl-tRNA synthetase from escherichia COLI complexed with methionine phosphinate · MPJ A553 · binds ALA12, LEU13, PRO14, TYR15, ASP52, TRP253, ALA256, PRO257 and 3 more
  • 3JWA · Crystal structure of L-methionine gamma-lyase from Citrobacter freundii with methionine… · MPJ A399 · binds TYR113, CYS115, LLP210, VAL338, SER339, LEU340, GLN348, ARG374
  • 1C24 · E. COLI methionine aminopeptidase: methionine phosphinate complex · MPJ A300 · binds CYS59, TYR62, TYR65, CYS70, HIS79, ASP97, THR99, ASP108 and 6 more
  • 1PFU · Methionyl-tRNA synthetase from escherichia COLI complexed with methionine phosphinate · MPJ A553 · binds ALA12, LEU13, PRO14, TYR15, ASP52, TRP253, ALA256, PRO257 and 3 more
  • 3JWA · Crystal structure of L-methionine gamma-lyase from citrobacter freundii with methionine… · MPJ A399 · binds TYR113, CYS115, LLP210, VAL338, SER339, LEU340, GLN348, ARG374

Residues it binds most

TYR 6, HIS 4, ASP 4, CYS 4, ALA 2, GLU 2, LEU 4, PRO 2, TRP 4, ARG 2 (residue and the binding sites it lines).

Found with

  • CO · Cobalt (II) ion
  • NA · Sodium ion
  • ZN · Zinc ion
  • PEG · Di(hydroxyethyl)ether

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