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Ligand · MNA

MNA · 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid

MNA, 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid (C12 H21 N O9, 323.3 g/mol), in the MolNFT structures on GenesisL1: bound in 19 records (10 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
MNA
Formula
C12 H21 N O9
Class
sugar
Structures
19
PDB entries
10

Binding sites

MNA in 19 structures; the first of them:

  • 1HGE · Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic… · MNA A349 · binds TYR98, GLY134, ARG135, SER136, ASN137, TRP153, THR155, HIS183 and 4 more
  • 1HGH · Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic… · MNA A349 · binds TYR98, GLY134, GLY135, SER136, ASN137, TRP153, THR155, HIS183 and 4 more
  • 1KQR · Crystal Structure of the Rhesus Rotavirus VP4 Sialic Acid Binding Domain in Complex with… · MNA A1000 · binds ARG101, VAL144, THR146, TYR155, LYS187, TYR188, TYR189, SER190
  • 2I2S · Crystal Structure of the porcine CRW-8 rotavirus VP8* carbohydrate-recognising domain · MNA A1000 · binds ARG101, SER144, HIS155, GLY156, ASN178, TYR188, TYR189, SER190
  • 2P3I · Crystal structure of Rhesus Rotavirus VP8* at 295K · MNA A1000 · binds ARG101, VAL144, THR146, TYR155, LYS187, TYR188, TYR189, SER190
  • 2P3J · Crystal structure of the Arg101Ala mutant protein of Rhesus rotavirus VP8* · MNA A1000 · binds VAL144, THR146, TYR155, LYS187, TYR188, TYR189, SER190
  • 2P3K · Crystal structure of Rhesus rotavirus VP8* at 100K · MNA A1000 · binds ARG101, VAL144, THR146, TYR155, GLY156, LYS187, TYR188, TYR189 and 1 more
  • 3IYK · Bluetongue virus structure reveals a sialic acid binding domain, amphipathic helices and… · MNA G1000 · binds LEU189, LYS190
  • 4XL8 · Crystal Structure of Human Adenovirus 52 Short Fiber Knob in Complex with… · MNA A401 · binds ARG316, GLY317, ASN318, SER302, GLY303, GLU304, PRO305, ASN308 and 1 more
  • 6Y66 · Structure of Goose Hemorrhagic Polyomavirus VP1 in complex with… · MNA AAA401 · binds THR57, VAL58, ALA59, THR60, PRO64, ASP65, VAL66, PRO67 and 2 more
  • 1HGE · Binding of influenza virus hemagglutinin to analogs of its cell- surface receptor, sialic… · MNA A349 · binds TYR98, GLY134, ARG135, SER136, ASN137, TRP153, THR155, HIS183 and 4 more
  • 1HGH · Binding of influenza virus hemagglutinin to analogs of its cell- surface receptor, sialic… · MNA A349 · binds TYR98, GLY134, GLY135, SER136, ASN137, TRP153, THR155, HIS183 and 4 more

Residues it binds most

TYR 36, SER 36, THR 34, GLU 24, ARG 28, GLY 22, PRO 14, LEU 18, VAL 20, ASN 22 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol
  • BMA · beta-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • MPD · (4S)-2-methyl-2,4-pentanediol
  • ALA · Alanine
  • GLU · Glutamic acid
  • TAM · Tris(hydroxyethyl)aminomethane
  • NA · Sodium ion
  • MRD · (4R)-2-methylpentane-2,4-diol
  • EDO · 1,2-ethanediol
  • IMD · Imidazole

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