GL1X · GenesisL1 explorer

Ligand · MI6

MI6 · (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

MI6, (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide (C29 H35 Cl2 F N4 O3, 577.5 g/mol), in the MolNFT structures on…

Component
MI6
Formula
C29 H35 Cl2 F N4 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

MI6 in 2 structures; the first of them:

  • 3LBL · Structure of human MDM2 protein in complex with Mi-63-analog · MI6 A1 · binds ILE19, LEU54, LEU57, GLY58, ILE61, MET62, TYR67, VAL75 and 7 more
  • 3LBL · Structure of human MDM2 protein in complex with mi-63-analog · MI6 A1 · binds ILE19, LEU54, LEU57, GLY58, ILE61, MET62, TYR67, VAL75 and 7 more

Residues it binds most

ILE 6, LEU 6, PHE 6, TYR 6, VAL 6, HIS 6, GLY 6, MET 6, GLN 2, GLU 2 (residue and the binding sites it lines).

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