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Ligand · MEK

MEK · 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(2-hydroxyethoxy)methyl]benzamide

MEK, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(2-hydroxyethoxy)methyl]benzamide (C18 H18 F3 I N2 O5, 526.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with…

Component
MEK
Formula
C18 H18 F3 I N2 O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

MEK in 2 structures; the first of them:

  • 3DV3 · MEK1 with PF-04622664 Bound · MEK A9001 · binds ASN78, GLY79, GLY80, LYS97, ILE99, LEU115, LEU118, VAL127 and 14 more
  • 3DV3 · MEK1 with pf-04622664 bound · MEK A9001 · binds ASN78, GLY79, GLY80, LYS97, ILE99, LEU115, LEU118, VAL127 and 14 more

Residues it binds most

GLY 2, ILE 2, LEU 2, ASP 2, MET 2, VAL 2, ARG 2, ASN 2, CYS 2, HIS 2 (residue and the binding sites it lines).

Found with

  • ATP · Adenosine-5'-triphosphate
  • MG · Magnesium ion
  • GOL · Glycerol

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