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Ligand · M7H

M7H · 1-[4-[2-(4-methoxyphenyl)-5-methyl-pyrrolo[2,3-b]pyrazin-6-yl]piperidin-1-yl]ethanone

M7H, 1-[4-[2-(4-methoxyphenyl)-5-methyl-pyrrolo[2,3-b]pyrazin-6-yl]piperidin-1-yl]ethanone (C21 H24 N4 O2, 364.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within…

Component
M7H
Formula
C21 H24 N4 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

M7H in 2 structures; the first of them:

  • 6T13 · Crystal structure of glucocerebrosidase in complex with a pyrrolopyrazine · M7H C502 · binds SER237, PRO245, PHE246, ASP283, GLN284, TYR313, LEU314, SER345 and 8 more
  • 6T13 · Crystal structure of glucocerebrosidase in complex with a pyrrolopyrazine · M7H C502 · binds PRO245, PHE246, GLN284, TYR313, LEU314, SER345, VAL394, ASN396 and 4 more

Residues it binds most

SER 4, PHE 4, ASP 4, ASN 4, GLN 4, GLU 4, LEU 4, PRO 4, TRP 4, TYR 4 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CL · Chloride ion
  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol
  • GOL · Glycerol
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol

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