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Ligand · LZ1

LZ1 · 1H-indazole

LZ1, 1H-indazole (C7 H6 N2, 118.1 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
LZ1
Formula
C7 H6 N2
Class
ligand
Structures
6
PDB entries
6

Binding sites

LZ1 in 6 structures; the first of them:

  • 5LK9 · Dehaloperoxidase B from amphitrite ornata: indazole complex · LZ1 A205 · binds PHE21, PHE35, TYR38, HIS55, THR56, VAL59
  • 5QUR · HUMRADA1 soaked with 2 mm indazole in 10% dmso · LZ1 A401 · binds MET169, TRP170, ILE171, ALA201, TYR202, ALA203, LEU214, ALA218
  • 5QUS · HUMRADA1 soaked with 5 mm indazole in 10% dmso · LZ1 A401 · binds MET169, TRP170, ILE171, ALA201, TYR202, ALA203, LEU214, ALA218
  • 5QUT · HUMRADA1 soaked with 10 mm indazole in 10% dmso · LZ1 A401 · binds MET169, TRP170, ILE171, ALA201, TYR202, ALA203, LEU214, ALA218
  • 5RVR · Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP3 macrodomain in… · LZ1 A201 · binds ALA70, THR71, GLY73, PRO74
  • 7O6R · Crystal structure of bovine HSC70(AA1-554)E213A/D214A in complex with 1H-indazole · LZ1 A902 · binds LEU401, GLU444, LEU456, ILE480, GLY484, LEU486, ILE503, THR504 and 2 more

Residues it binds most

ALA 4, LEU 4, ILE 4, PHE 2, THR 4, TYR 4, MET 3, TRP 3, GLY 2, HIS 2 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion
  • DMS · Dimethyl sulfoxide
  • GOL · Glycerol
  • HEM · Protoporphyrin IX containing Fe
  • TMO · trimethylamine oxide
  • K · Potassium ion
  • SO4 · Sulfate ion
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid

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