GL1X · GenesisL1 explorer

Ligand · LTZ

LTZ · (5R,6S)-2-[((2S,5R)-2-{[(3R)-4-acetyl-3-methylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidin-1-yl)carbonyl]-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole

LTZ, (5R,6S)-2-[((2S,5R)-2-{[(3R)-4-acetyl-3-methylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidin-1-yl)carbonyl]-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole (C36 H43 Cl2 N5 O3 S, 696.7 g/mol), in the…

Component
LTZ
Formula
C36 H43 Cl2 N5 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

LTZ in 2 structures; the first of them:

  • 3W69 · Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor · LTZ A201 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, GLN72, ILE74 and 6 more
  • 3W69 · Crystal structure of human MDM2 with a dihydroimidazothiazole inhibitor · LTZ A201 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, GLN72, ILE74 and 6 more

Residues it binds most

ILE 4, LEU 4, TYR 4, VAL 4, PHE 4, GLN 4, GLY 4, HIS 4, MET 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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