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Ligand · LKF

LKF · 4-[3-[1-[(2S)-2-methoxypropyl]pyrazol-4-yl]-2-methyl-imidazo[1,2-a]pyrazin-8-yl]morpholine

LKF, 4-[3-[1-[(2S)-2-methoxypropyl]pyrazol-4-yl]-2-methyl-imidazo[1,2-a]pyrazin-8-yl]morpholine (C18 H24 N6 O2, 356.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
LKF
Formula
C18 H24 N6 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

LKF in 2 structures; the first of them:

  • 4BBX · Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of… · LKF A1760 · binds TYR514, SER561, SER563, LEU625, LEU665, SER667, VAL668, THR678 and 8 more
  • 4BBX · Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of… · LKF A1760 · binds TYR514, SER561, SER563, LEU625, LEU665, SER667, VAL668, THR678 and 8 more

Residues it binds most

PHE 4, LEU 4, SER 4, TYR 4, MET 4, ALA 4, GLN 4, ILE 4, THR 4, VAL 4 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • ZN · Zinc ion

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