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Ligand · LIS

LIS · (2S,4S)-2-amino-4,5-epoxipentanoic acid

LIS, (2S,4S)-2-amino-4,5-epoxipentanoic acid (C5 H9 N O3, 131.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
LIS
Formula
C5 H9 N O3
Class
ligand
Structures
4
PDB entries
2

Binding sites

LIS in 4 structures; the first of them:

  • 1O90 · Methionine Adenosyltransferase complexed with a L-methionine analogue · LIS A1397 · binds ASP180, LYS182, SER207, SER248, ARG250, PHE251
  • 1O93 · Methionine Adenosyltransferase complexed with ATP and a L-methionine analogue · LIS A1398 · binds SER248, ARG250, PHE251
  • 1O90 · Methionine adenosyltransferase complexed with a L-methionine analogue · LIS A1397 · binds ASP180, LYS182, SER207, SER248, ARG250, PHE251
  • 1O93 · Methionine adenosyltransferase complexed with ATP and a L-methionine analogue · LIS A1398 · binds SER248, ARG250, PHE251

Residues it binds most

SER 4, ARG 4, PHE 4, ASP 2, LYS 2 (residue and the binding sites it lines).

Found with

  • K · Potassium ion
  • MG · Magnesium ion
  • PO4 · Phosphate ion
  • ATP · Adenosine-5'-triphosphate

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