GL1X · GenesisL1 explorer

Ligand · LGF

LGF · 1-[5-[[3-[2,4-bis(fluoranyl)phenyl]-6,8-dihydro-5~{H}-imidazo[1,5-a]pyrazin-7-yl]carbonyl]-6-methoxy-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-[(3~{R})-3-oxidanylpyrrolidin-1-yl]ethane-1,2-dione

LGF, 1-[5-[[3-[2,4-bis(fluoranyl)phenyl]-6,8-dihydro-5~{H}-imidazo[1,5-a]pyrazin-7-yl]carbonyl]-6-methoxy-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-[(3~{R})-3-oxidanylpyrrolidin-1-yl]ethane-1,2-dione (C27 H24 F2 N6 O5, 550.5 g/mol), in the…

Component
LGF
Formula
C27 H24 F2 N6 O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

LGF in 2 structures; the first of them:

  • 2QD9 · P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds · LGF A361 · binds VAL30, GLY33, VAL38, ALA51, VAL52, LYS53, GLU71, LEU75 and 16 more
  • 2QD9 · P38 alpha MAP kinase inhibitor based on heterobicyclic scaffolds · LGF A361 · binds VAL30, GLY33, VAL38, ALA51, VAL52, LYS53, GLU71, LEU75 and 16 more

Residues it binds most

LEU 2, VAL 2, ALA 2, GLY 2, ASN 2, ASP 2, GLU 2, HIS 2, ILE 2, LYS 2 (residue and the binding sites it lines).

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