Ligand · LFE
LFE · ~{N}-[(5~{S},7~{R},11~{S},23~{S})-11-~{tert}-butyl-34-(4-methyl-1,3-thiazol-5-yl)-7-oxidanyl-4,10,13-tris(oxidanylidene)-15,18,21,25,28,31-hexaoxa-3,9,12-triazatricyclo[30.4.0.0^{5,9}]hexatriaconta-1(32),33, 35-trien-23-yl]-2-[(7~{S},9~{S})-7-(4-chlorophenyl)-4, 5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,10,12-tetraen-9-yl]ethanamide
LFE, ~{N}-[(5~{S},7~{R},11~{S},23~{S})-11-~{tert}-butyl-34-(4-methyl-1,3-thiazol-5-yl)-7-oxidanyl-4,10,13-tris(oxidanylidene)-15,18,21,25,28,31-hexaoxa-3,9,12-triazatricyclo[30.4.0.0^{5,9}]hexatriaconta-1(32),33…
- Component
- LFE
- Formula
- C54 H70 Cl N9 O11 S2
- Class
- ligand
- Structures
- 1
- PDB entries
- 1
Binding sites
LFE in 1 structure; the first of them:
- 6SIS · Crystal structure of macrocyclic protac 1 in complex with the second bromodomain of human… · LFE D301 · binds TRP374, PRO375, PHE376, VAL380, ALA384, LEU385, GLY386, LEU387 and 19 more
Residues it binds most
HIS 2, LEU 2, TRP 2, TYR 2, PHE 2, PRO 2, VAL 2, ASN 2, ALA 2, ARG 2 (residue and the binding sites it lines).
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