Ligand · LC6
LC6 · 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid
LC6, 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid (C47 H46 N6 O8 S2, 887.0 g/mol), in the…
- Component
- LC6
- Formula
- C47 H46 N6 O8 S2
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
LC6 in 4 structures; the first of them:
- 3WIY · Crystal structure of Mcl-1 in complex with compound 10 · LC6 A501 · binds HIS224, THR226, ALA227, PHE228, GLY230, MET231, ARG233, LYS234 and 14 more
- 3WIZ · Crystal structure of Bcl-xL in complex with compound 10 · LC6 A501 · binds ALA93, GLU96, PHE97, ARG100, TYR101, PHE105, LEU108, VAL126 and 10 more
- 3WIY · Crystal structure of mcl-1 in complex with compound 10 · LC6 A501 · binds HIS224, THR226, ALA227, PHE228, GLY230, MET231, ARG233, LYS234 and 14 more
- 3WIZ · Crystal structure of BCL-xl in complex with compound 10 · LC6 A501 · binds ALA93, GLU96, PHE97, ARG100, TYR101, PHE105, LEU108, VAL126 and 10 more
Residues it binds most
LEU 16, PHE 16, VAL 16, ARG 16, MET 12, ALA 16, GLY 16, HIS 12, THR 12, ILE 12 (residue and the binding sites it lines).
Found with
- PO4 · Phosphate ion
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