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Ligand · LB3

LB3 · (9R,10R,11S,12R,13R,14R)-4-amino-9-(3,4-difluorophenyl)-6,7,8,9,10,11,12,13-octahydro-10,13-epoxy[1,3]diazecino[1,2-e]purine-11,12-diol

LB3, (9R,10R,11S,12R,13R,14R)-4-amino-9-(3,4-difluorophenyl)-6,7,8,9,10,11,12,13-octahydro-10,13-epoxy[1,3]diazecino[1,2-e]purine-11,12-diol (C18 H18 F2 N6 O3, 404.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
LB3
Formula
C18 H18 F2 N6 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

LB3 in 2 structures; the first of them:

  • 7U30 · PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1 · LB3 A707 · binds PRO314, LEU315, LEU319, THR323, TYR324, PHE327, TYR334, GLY365 and 13 more
  • 7U30 · PRMT5:MEP50 complexed with cyclonucleoside compound 1 · LB3 A707 · binds PRO314, LEU315, LEU319, TYR324, PHE327, TYR334, GLY365, GLY367 and 10 more

Residues it binds most

LEU 2, GLU 2, GLY 2, TYR 2, ARG 2, ASN 2, ASP 2, CYS 2, LYS 2, MET 2 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol

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