GL1X · GenesisL1 explorer

Ligand · L1X

L1X · N-(3-fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

L1X, N-(3-fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide (C30 H22 F2 N6 O3, 552.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1…

Component
L1X
Formula
C30 H22 F2 N6 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

L1X in 2 structures; the first of them:

  • 7AAY · Crystal structure of MerTK kinase domain in complex with Merestinib · L1X A901 · binds LEU593, GLY594, GLU595, GLY596, VAL601, ALA617, LYS619, GLU637 and 17 more
  • 7AAY · Crystal structure of mertk kinase domain in complex with merestinib · L1X A901 · binds GLY594, GLU595, VAL601, ALA617, LYS619, GLU637, CYS640, MET641 and 15 more

Residues it binds most

PHE 2, MET 2, VAL 2, LEU 2, ALA 2, GLU 2, GLY 2, ASP 2, CYS 2, HIS 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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