GL1X · GenesisL1 explorer

Ligand · KWZ

KWZ · 4-(3-piperidin-1-ylpropyl)-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile

KWZ, 4-(3-piperidin-1-ylpropyl)-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile (C20 H21 F3 N4, 374.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5…

Component
KWZ
Formula
C20 H21 F3 N4
Class
ligand
Structures
2
PDB entries
1

Binding sites

KWZ in 2 structures; the first of them:

  • 3KWZ · Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor · KWZ A222 · binds GLN19, GLY23, SER24, CYS25, TRP26, CYS63, GLY64, GLY65 and 9 more
  • 3KWZ · Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor · KWZ A222 · binds GLN19, GLY23, SER24, CYS25, TRP26, CYS63, GLY64, GLY65 and 9 more

Residues it binds most

GLY 2, ALA 2, CYS 2, LEU 2, ASN 2, GLN 2, HIS 2, MET 2, SER 2, TRP 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.