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Ligand · KL0

KL0 · 6-[3-(dimethylamino)propyl]-4-methylpyridin-2-amine

KL0, 6-[3-(dimethylamino)propyl]-4-methylpyridin-2-amine (C11 H19 N3, 193.3 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most…

Component
KL0
Formula
C11 H19 N3
Class
ligand
Structures
6
PDB entries
3

Binding sites

KL0 in 6 structures; the first of them:

  • 7TS8 · Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in… · KL0 A803 · binds GLN483, PRO570, VAL572, PHE589, SER590, GLY591, TRP592, TYR593 and 2 more
  • 7TS9 · Structure of rat neuronal nitric oxide synthase R349A heme domain in complex with… · KL0 A803 · binds GLN478, PRO565, ALA566, VAL567, PHE584, SER585, GLY586, TRP587 and 3 more
  • 7TSG · Structure of human endothelial nitric oxide synthase heme domain in complex with… · KL0 A503 · binds GLN247, PRO334, VAL336, PHE353, SER354, GLY355, TRP356, TYR357 and 2 more
  • 7TS8 · Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in… · KL0 A803 · binds GLN483, PRO570, VAL572, PHE589, SER590, GLY591, TRP592, TYR593 and 2 more
  • 7TS9 · Structure of rat neuronal nitric oxide synthase R349A heme domain in complex with… · KL0 A803 · binds GLN478, PRO565, ALA566, VAL567, PHE584, SER585, GLY586, TRP587 and 3 more
  • 7TSG · Structure of human endothelial nitric oxide synthase heme domain in complex with… · KL0 A503 · binds GLN247, PRO334, VAL336, PHE353, SER354, GLY355, TRP356, TYR357 and 2 more

Residues it binds most

GLN 18, GLU 18, GLY 18, MET 18, PHE 18, PRO 18, SER 18, TRP 18, TYR 18, VAL 18 (residue and the binding sites it lines).

Found with

  • H4B · 5,6,7,8-tetrahydrobiopterin
  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • GOL · Glycerol
  • GD · Gadolinium atom
  • CL · Chloride ion
  • ACT · Acetate ion
  • BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol

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