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Ligand · KKF

KKF · 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

KKF, 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one (C23 H21 Cl3 N2 O3, 479.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
KKF
Formula
C23 H21 Cl3 N2 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

KKF in 2 structures; the first of them:

  • 7TUY · Cryo-EM structure of GSK682753A-bound EBI2/GPR183 · KKF R1301 · binds MET34, TYR38, ARG87, TYR90, THR107, PHE111, TYR112, LEU166 and 9 more
  • 7TUY · Cryo-EM structure of GSK682753A-bound EBI2/GPR183 · KKF R1301 · binds MET34, TYR38, ARG87, TYR90, PHE111, TYR112, LEU166, TYR184 and 6 more

Residues it binds most

TYR 2, LEU 2, ARG 2, ASN 2, HIS 2, ILE 2, MET 2, PHE 2, VAL 2, GLU 1 (residue and the binding sites it lines).

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