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Ligand · KA7

KA7 · N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-5-chloro-2-methoxypyridine-3-sulfonamide

KA7, N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-5-chloro-2-methoxypyridine-3-sulfonamide (C18 H12 Cl F2 N5 O3 S, 451.8 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with…

Component
KA7
Formula
C18 H12 Cl F2 N5 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

KA7 in 2 structures; the first of them:

  • 6N3O · Identification of novel, potent and selective GCN2 inhibitors as first-in-class… · KA7 A2500 · binds LEU596, VAL604, ALA617, VAL618, LYS619, VAL637, LEU640, SER641 and 16 more
  • 6N3O · Identification of novel, potent and selective GCN2 inhibitors as first-in-class… · KA7 A2500 · binds LEU596, VAL604, ALA617, VAL618, LYS619, VAL637, LEU640, ILE648 and 12 more

Residues it binds most

VAL 2, LEU 2, ILE 2, PHE 2, TYR 2, GLY 2, ALA 2, ASP 2, CYS 2, GLU 2 (residue and the binding sites it lines).

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