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Ligand · KA4

KA4 · N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide

KA4, N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide (C19 H12 Cl2 F2 N4 O3 S, 485.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
KA4
Formula
C19 H12 Cl2 F2 N4 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

KA4 in 2 structures; the first of them:

  • 6N3N · Identification of novel, potent and selective GCN2 inhibitors as first-in-class… · KA4 A2500 · binds LEU596, VAL604, ALA617, VAL618, LYS619, LEU640, SER641, LEU643 and 13 more
  • 6N3N · Identification of novel, potent and selective GCN2 inhibitors as first-in-class… · KA4 A2500 · binds LEU596, VAL604, ALA617, VAL618, LYS619, LEU640, SER641, LEU643 and 13 more

Residues it binds most

LEU 2, VAL 2, ILE 2, PHE 2, TYR 2, ALA 2, ASP 2, CYS 2, GLU 2, GLY 2 (residue and the binding sites it lines).

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