GL1X · GenesisL1 explorer

Ligand · JZP

JZP · (4R)-3-[(2S,3S)-3-{[(2,6-dichlorophenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

JZP, (4R)-3-[(2S,3S)-3-{[(2,6-dichlorophenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (C33 H35 Cl2 N3 O6 S, 672.6 g/mol), in the MolNFT…

Component
JZP
Formula
C33 H35 Cl2 N3 O6 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

JZP in 2 structures; the first of them:

  • 3KDC · Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I) in Complex with KNI-10074 · JZP A100 · binds ARG8, LEU23, ASP25, GLY27, ALA28, ASP29, ASP30, VAL32 and 21 more
  • 3KDC · Crystal structure of HIV-1 protease (Q7K, L33I, L63I) in complex with kni-10074 · JZP A100 · binds ARG8, LEU23, ASP25, GLY27, ALA28, ASP29, ASP30, VAL32 and 21 more

Residues it binds most

ASP 2, GLY 2, ILE 2, VAL 2, LEU 2, ALA 2, ARG 2, PRO 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • GOL · Glycerol

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