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Ligand · JUO

JUO · 2-amino-4-thiomorpholino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

JUO, 2-amino-4-thiomorpholino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (C11 H12 N6 S, 260.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues…

Component
JUO
Formula
C11 H12 N6 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

JUO in 2 structures; the first of them:

  • 4CLD · Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary… · JUO A1270 · binds ARG14, PHE97, ASP161, MET163, CYS168, TYR174, GLY205, VAL206 and 5 more
  • 4CLD · Crystal structure of pteridine reductase 1 (PTR1) from trypanosoma brucei in ternary… · JUO A1270 · binds ARG14, PHE97, ASP161, MET163, CYS168, TYR174, GLY205, VAL206 and 5 more

Residues it binds most

LEU 8, MET 6, ARG 8, ASP 8, CYS 8, GLY 8, PHE 8, PRO 8, SER 8, TRP 8 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate
  • ACT · Acetate ion

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