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Ligand · JKF

JKF · 6-[(R)-(4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl]-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one

JKF, 6-[(R)-(4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl]-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one (C28 H22 Cl F2 N3 O2, 505.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
JKF
Formula
C28 H22 Cl F2 N3 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

JKF in 2 structures; the first of them:

  • 3TIK · Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the… · JKF A490 · binds TYR103, PHE105, MET106, PHE110, ALA115, TYR116, LEU127, GLU205 and 10 more
  • 3TIK · Sterol 14-alpha demethylase (CYP51) from trypanosoma brucei in complex with the… · JKF A490 · binds TYR103, PHE105, MET106, PHE110, ALA115, TYR116, LEU127, GLU205 and 10 more

Residues it binds most

LEU 8, ALA 8, MET 8, PHE 8, TYR 8, CYS 8, THR 8, VAL 8, GLU 4, PRO 2 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe

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