Ligand · JFR
JFR · 2-(2-cyclopentyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-5-methyl-furo[3,2-c]pyridin-4-one
JFR, 2-(2-cyclopentyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-5-methyl-furo[3,2-c]pyridin-4-one (C33 H34 F N3 O4, 555.6 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records…
- Component
- JFR
- Formula
- C33 H34 F N3 O4
- Class
- ligand
- Structures
- 3
- PDB entries
- 2
Binding sites
JFR in 3 structures; the first of them:
- 7WLN · Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor… · JFR A501 · binds TRP370, PRO371, PHE372, PRO375, VAL376, ASP377, LEU381, LEU383 and 8 more
- 7WKY · Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor… · JFR A201 · binds TRP81, PRO82, PHE83, GLN85, PRO86, VAL87, ASP88, LEU92 and 5 more
- 7WLN · Crystal structure of the second bromodomain of human BRD2 in complex with the inhibitor… · JFR A501 · binds TRP370, PRO371, PHE372, PRO375, VAL376, ASP377, LEU381, LEU383 and 7 more
Residues it binds most
PRO 11, LEU 11, VAL 11, ASP 11, TRP 11, ASN 11, PHE 11, MET 9, CYS 8, HIS 7 (residue and the binding sites it lines).
Found with
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