Ligand · JFL
JFL · 2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl) phenyl]-5-methyl-furo[3,2-c]pyridin-4-one
JFL, 2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl) phenyl]-5-methyl-furo[3,2-c]pyridin-4-one (C32 H32 F N3 O4, 541.6 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records…
- Component
- JFL
- Formula
- C32 H32 F N3 O4
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
JFL in 4 structures; the first of them:
- 7WJS · Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor… · JFL A201 · binds TRP81, PRO82, PHE83, GLN85, PRO86, VAL87, ASP88, LEU92 and 9 more
- 7WMQ · Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor… · JFL A501 · binds TRP370, PRO371, PHE372, PRO375, VAL376, ASP377, LEU381, LEU383 and 8 more
- 7WJS · Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor… · JFL A201 · binds TRP81, PRO82, PHE83, GLN85, PRO86, VAL87, LEU92, LEU94 and 3 more
- 7WMQ · Crystal structure of the second bromodomain of human BRD2 in complex with the inhibitor… · JFL A501 · binds TRP370, PRO371, PHE372, PRO375, VAL376, ASP377, LEU381, LEU383 and 7 more
Residues it binds most
PRO 14, LEU 14, ASP 13, VAL 14, TRP 14, ASN 14, PHE 14, TYR 11, MET 12, CYS 11 (residue and the binding sites it lines).
Found with
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