Ligand · JAU
JAU · 5-chloranyl-N2-[3-chloranyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine
JAU, 5-chloranyl-N2-[3-chloranyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine (C28 H36 Cl2 N7 O P, 588.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…
- Component
- JAU
- Formula
- C28 H36 Cl2 N7 O P
- Class
- ligand
- Structures
- 2
- PDB entries
- 1
Binding sites
JAU in 2 structures; the first of them:
- 7ER2 · Crystal structure of EGFR 696-1022 T790M/C797S in complex with LS_2_40 · JAU A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, MET790, GLN791 and 12 more
- 7ER2 · Crystal structure of EGFR 696-1022 T790M/C797S in complex with LS_2_40 · JAU A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, MET790, GLN791 and 12 more
Residues it binds most
LEU 2, ASP 2, GLY 2, MET 2, PHE 2, ALA 2, ARG 2, ASN 2, GLN 2, GLU 2 (residue and the binding sites it lines).
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