GL1X · GenesisL1 explorer

Ligand · IWH

IWH · 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide

IWH, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (C15 H16 N2 O2, 256.3 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues…

Component
IWH
Formula
C15 H16 N2 O2
Class
ligand
Structures
16
PDB entries
8

Binding sites

IWH in 16 structures; the first of them:

  • 3PN1 · Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and… · IWH A320 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCO · Fragment bound to H.influenza NAD dependent DNA ligase · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCR · Fragment bound to H.influenza NAD dependent DNA ligase · IWH A1318 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCS · Fragment bound to H.influenza NAD dependent DNA ligase · IWH A1318 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCT · Fragment bound to H.influenza NAD dependent DNA ligase · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCU · Fragment bound to H.influenza NAD dependent DNA ligase · IWH A1320 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCV · Fragment bound to H.influenza NAD dependent DNA ligase · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UFZ · Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling… · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 3PN1 · Novel bacterial NAD+-dependent DNA ligase inhibitors with broad spectrum potency and… · IWH A320 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCO · Fragment bound to H.INFLUENZA NAD dependent DNA ligase · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCR · Fragment bound to H.INFLUENZA NAD dependent DNA ligase · IWH A1318 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCS · Fragment bound to H.INFLUENZA NAD dependent DNA ligase · IWH A1318 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCT · Fragment bound to H.INFLUENZA NAD dependent DNA ligase · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCU · Fragment bound to H.INFLUENZA NAD dependent DNA ligase · IWH A1320 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UCV · Fragment bound to H.INFLUENZA NAD dependent DNA ligase · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more
  • 4UFZ · Synthesis of novel NAD dependant DNA ligase inhibitors via negishi cross-coupling… · IWH A1319 · binds TYR18, GLU19, TYR22, HIS23, PRO28, VAL30, PRO31, ASP32 and 2 more

Residues it binds most

TYR 16, ASP 16, PRO 16, GLU 16, HIS 16, VAL 16 (residue and the binding sites it lines).

Found with

  • 5U1 · 2-amino-6-methyl-5-(propan-2-yloxy)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium
  • 8HC · 8-hydroxyquinoline-2-carboxylic acid
  • 9MJ · 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
  • D41 · 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
  • I6G · 8-methoxy-2,3-dimethylquinoxalin-5-ol
  • IA7 · 5,7-bis(azanyl)-2-tert-butyl-4-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidine-6-carbonitrile
  • IVH · 2-(butylsulfanyl)adenosine
  • JCF · 8-hydroxy-2-methylquinoline-6-carboxamide

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.