GL1X · GenesisL1 explorer

Ligand · IUS

IUS · (1s,3s)-N-({4-[5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl]bicyclo[2.2.2]octan-1-yl}methyl)-3-hydroxy-N-[4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]-3-(trifluoromethyl)cyclobutane-1-carboxamide

IUS, (1s,3s)-N-({4-[5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl]bicyclo[2.2.2]octan-1-yl}methyl)-3-hydroxy-N-[4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]-3-(trifluoromethyl)cyclobutane-1-carboxamide (C35 H41 F4 N3 O4, 643.7 g/mol), in…

Component
IUS
Formula
C35 H41 F4 N3 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

IUS in 2 structures; the first of them:

  • 7TRB · Crystal structure of farnesoid X-activated receptor complexed with compound-32 aka… · IUS A501 · binds THR274, ILE277, PHE282, ASN287, ILE290, LEU291, THR292, MET294 and 24 more
  • 7TRB · Crystal structure of farnesoid X-activated receptor complexed with compound-32 aka… · IUS A501 · binds THR274, ILE277, PHE282, ASN287, ILE290, LEU291, THR292, MET294 and 24 more

Residues it binds most

LEU 4, ILE 4, MET 4, PHE 4, HIS 4, SER 4, TRP 4, TYR 4, THR 4, ALA 4 (residue and the binding sites it lines).

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