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Ligand · IRZ

IRZ · N~2~-({[(1R,2R)-2-(3-chlorophenyl) cyclopropyl]methoxy}carbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide

IRZ, N~2~-({[(1R,2R)-2-(3-chlorophenyl) cyclopropyl]methoxy}carbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (C24 H32 Cl N3 O5, 478.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
IRZ
Formula
C24 H32 Cl N3 O5
Class
ligand
Structures
2
PDB entries
1

Binding sites

IRZ in 2 structures; the first of them:

  • 7TQ4 · Structure of SARS-CoV-2 3CL protease in complex with the cyclopropane based inhibitor 6c · IRZ A401 · binds HIS41, MET49, TYR54, PHE140, LEU141, ASN142, GLY143, SER144 and 13 more
  • 7TQ4 · Structure of SARS-cov-2 3CL protease in complex with the cyclopropane based inhibitor 6C · IRZ A401 · binds HIS41, MET49, TYR54, PHE140, LEU141, ASN142, GLY143, SER144 and 13 more

Residues it binds most

HIS 2, LEU 2, MET 2, ALA 2, ARG 2, ASN 2, ASP 2, CYS 2, GLN 2, GLU 2 (residue and the binding sites it lines).

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