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Ligand · IHM

IHM · N-(3-{1-[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide

IHM, N-(3-{1-[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide (C29 H28 F2 N4 O4, 534.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
IHM
Formula
C29 H28 F2 N4 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

IHM in 2 structures; the first of them:

  • 3V9B · Crystal structure of the catalytic domain of PDE4D2 with… · IHM A1 · binds TYR159, HIS160, SER208, GLU230, THR271, ASP272, MET273, ASP318 and 16 more
  • 3V9B · Crystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1… · IHM A1 · binds TYR159, HIS160, SER208, GLU230, THR271, ASP272, MET273, ASP318 and 16 more

Residues it binds most

MET 8, ASP 8, GLN 8, ILE 8, PHE 8, SER 8, THR 8, TYR 8, ASN 8, CYS 8 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion

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