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Ligand · I29

I29 · [(4S,5R)-4,5-bis(4-chlorophenyl)-2,4,5-trimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone

I29, [(4S,5R)-4,5-bis(4-chlorophenyl)-2,4,5-trimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone (C27 H34 Cl2 N4 O3 S, 565.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
I29
Formula
C27 H34 Cl2 N4 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

I29 in 2 structures; the first of them:

  • 4J7E · The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529 · I29 A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, PHE87, VAL89 and 3 more
  • 4J7E · The 1.63A crystal structure of humanized xenopus MDM2 with a nutlin fragment, RO5524529 · I29 A201 · binds LEU50, LEU53, GLY54, ILE57, MET58, TYR63, PHE87, VAL89 and 3 more

Residues it binds most

ILE 2, LEU 2, TYR 2, GLY 2, HIS 2, MET 2, PHE 2, VAL 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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