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Ligand · HWU

HWU · (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate

HWU, (2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (C17 H27 N3 O16 P2…

Component
HWU
Formula
C17 H27 N3 O16 P2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

HWU in 2 structures; the first of them:

  • 4D0Z · GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset) · HWU A1582 · binds THR143, PHE144, HIS145, GLU147, ASP176, ARG201, GLY203, LEU204 and 19 more
  • 4D0Z · Galnac-T2 crystal soaked with udp-5SGALNAC, MEA2 and manganese (higher resolution dataset) · HWU A1582 · binds THR143, PHE144, HIS145, GLU147, ASP176, ARG201, GLY203, LEU204 and 19 more

Residues it binds most

GLY 12, HIS 12, ARG 12, ASP 12, GLU 12, LEU 12, SER 12, THR 12, ALA 12, ASN 12 (residue and the binding sites it lines).

Found with

  • MN · Manganese (II) ion
  • BBK · 2-acetamido-2-deoxy-5-thio-alpha-D-galactopyranose
  • EDO · 1,2-ethanediol

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