GL1X · GenesisL1 explorer

Ligand · HVL

HVL · (3R,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5, 6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

HVL, (3R,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5, 6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol (C30 H52 O4, 476.7 g/mol), in the MolNFT structures…

Component
HVL
Formula
C30 H52 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

HVL in 2 structures; the first of them:

  • 7E3M · RORgamma LBD complexed with Panaxatriol and SRC2.2 · HVL A601 · binds GLN286, LEU287, TRP317, CYS320, ALA321, HIS323, LEU324, ALA327 and 14 more
  • 7E3M · Rorgamma lbd complexed with panaxatriol and SRC2.2 · HVL A601 · binds GLN286, LEU287, TRP317, CYS320, ALA321, HIS323, LEU324, ALA327 and 14 more

Residues it binds most

LEU 2, ALA 2, PHE 2, CYS 2, HIS 2, ILE 2, VAL 2, GLN 2, MET 2, TRP 2 (residue and the binding sites it lines).

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