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Ligand · HRZ

HRZ · 1~{H}-pyridin-2-one

HRZ, 1~{H}-pyridin-2-one (C5 H5 N O, 95.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
HRZ
Formula
C5 H5 N O
Class
ligand
Structures
4
PDB entries
3

Binding sites

HRZ in 4 structures; the first of them:

  • 5S48 · PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 Nsp3 macrodomain in… · HRZ A401 · binds ASP22, GLY48, VAL49, ALA52, PHE156
  • 5S48 · Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP3 macrodomain in… · HRZ A401 · binds ASP22, GLY48, VAL49, ALA52, PHE156
  • 6QA4 · ERK2 mini-fragment binding · HRZ A402 · binds ILE243, LYS272, VAL273, PRO274, TRP275, ASP291
  • 6TX4 · Crystal structure of human FKBP51 FK1 domain A19T mutant in complex with 2-pyridone · HRZ A204 · binds TYR57, ASP68, PHE77, VAL86, ILE87, TRP90, TYR113, PHE130

Residues it binds most

VAL 6, ASP 5, ILE 3, TYR 4, ALA 4, ASN 2, LYS 4, PHE 3, LEU 2, THR 2 (residue and the binding sites it lines).

Found with

  • DMS · Dimethyl sulfoxide
  • NA · Sodium ion
  • CL · Chloride ion
  • SO4 · Sulfate ion

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