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Ligand · HRH

HRH · (4~{S})-5-(3-chloranyl-2-fluoranyl-phenyl)-4-(4-chloranyl-2-methyl-phenyl)-3-propan-2-yl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one

HRH, (4~{S})-5-(3-chloranyl-2-fluoranyl-phenyl)-4-(4-chloranyl-2-methyl-phenyl)-3-propan-2-yl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one (C21 H18 Cl2 F N3 O, 418.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
HRH
Formula
C21 H18 Cl2 F N3 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

HRH in 2 structures; the first of them:

  • 6Q9H · HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 11 AT 2.0A; Structural states of Hdm2… · HRH A201 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, PHE86, PHE91 and 4 more
  • 6Q9H · HDM2 (17-111, wild type) complexed with compound 11 at 2.0A; structural states of HDM2… · HRH A201 · binds LEU54, LEU57, GLY58, ILE61, MET62, TYR67, PHE86, VAL93 and 3 more

Residues it binds most

ILE 2, LEU 2, TYR 2, PHE 2, GLY 2, HIS 2, MET 2, VAL 2 (residue and the binding sites it lines).

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