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Ligand · HPU

HPU · N-[3-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenyl]methanesulfonamide

HPU, N-[3-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenyl]methanesulfonamide (C18 H16 N2 O4 S, 356.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5…

Component
HPU
Formula
C18 H16 N2 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

HPU in 2 structures; the first of them:

  • 3W0T · Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor · HPU A202 · binds HIS126, MET157, LEU160, PHE162, GLU172, MET179, LEU182, MET183 and 12 more
  • 3W0T · Human glyoxalase I with an N-hydroxypyridone derivative inhibitor · HPU A202 · binds HIS126, MET157, LEU160, PHE162, GLU172, MET179, LEU182, MET183 and 12 more

Residues it binds most

MET 8, LEU 8, PHE 8, GLU 8, CYS 8, GLN 8, HIS 8, ILE 8, THR 8, ARG 6 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid

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