H7B · 2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone

Binding sites

H7B in 4 structures; the first of them:

• 6I7X · Crystal Structure of the first bromodomain of BRD4 in complex with RT53 · H7B A204 · binds TRP81, PRO82, PHE83, GLN85, VAL87, LEU92, LEU94, TYR97 and 6 more
• 6I80 · Crystal Structure of the second bromodomain of BRD2 in complex with RT53 · H7B A501 · binds TRP370, PRO371, PHE372, VAL376, LEU381, LEU383, CYS425, TYR428 and 6 more
• 6I7X · Crystal structure of the first bromodomain of BRD4 in complex with RT53 · H7B A204 · binds TRP81, PRO82, PHE83, LEU92, LEU94, TYR139, ASN140, ASP145 and 2 more
• 6I80 · Crystal structure of the second bromodomain of BRD2 in complex with RT53 · H7B A501 · binds TRP370, PRO371, PHE372, VAL376, LEU383, CYS425, TYR428, ASN429 and 5 more

Residues it binds most

LEU 6, PRO 6, VAL 5, TYR 6, ASN 6, ASP 6, MET 6, PHE 6, TRP 6, CYS 5 (residue and the binding sites it lines).

Found with

• EDO · 1,2-ethanediol