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Ligand · GW8

GW8 · 1-(4-{methyl[2-({4-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]amino}phenyl)-3-{3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea

GW8, 1-(4-{methyl[2-({4-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]amino}phenyl)-3-{3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea (C32 H36 N8 O4 S, 628.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
GW8
Formula
C32 H36 N8 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

GW8 in 2 structures; the first of them:

  • 4AOT · Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A · GW8 A1319 · binds LEU42, PHE47, VAL50, ALA63, LYS65, ILE67, TYR78, GLU81 and 14 more
  • 4AOT · Crystal structure of human serine threonine kinase-10 (lok) bound to GW830263A · GW8 A1319 · binds LEU42, PHE47, VAL50, ALA63, LYS65, ILE67, TYR78, GLU81 and 14 more

Residues it binds most

ILE 4, ALA 4, PHE 4, GLU 4, LEU 4, GLY 4, ASP 4, CYS 4, LYS 4, TYR 4 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion

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