GL1X · GenesisL1 explorer

Ligand · GVZ

GVZ · (2~{S})-~{N}-[(2~{S},3~{R})-1-[(1~{S},4~{A}~{S}, 8~{A}~{R})-1,2,3,4,4~{A},5,6,7,8,8~{A}-decahydronaphthalen-1-yl]-4-methyl-3,4-bis(oxidanyl) pentan-2-yl]-3-(4-methoxyphenyl)-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide

GVZ, (2~{S})-~{N}-[(2~{S},3~{R})-1-[(1~{S},4~{A}~{S}, 8~{A}~{R})-1,2,3,4,4~{A},5,6,7,8,8~{A}-decahydronaphthalen-1-yl]-4-methyl-3,4-bis(oxidanyl) pentan-2-yl]-3-(4-methoxyphenyl)-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino)…

Component
GVZ
Formula
C35 H56 N4 O7
Class
ligand
Structures
1
PDB entries
1

Binding sites

GVZ in 1 structure; the first of them:

  • 6HVY · Yeast 20S proteasome in complex with 5 (7- and 6-membered ring) · GVZ H301 · binds THR1, ARG19, SER20, THR21, GLN22, CYS31, ALA32, LYS33 and 12 more

Residues it binds most

THR 2, ALA 2, GLY 2, SER 2, ARG 2, ASP 2, CYS 2, GLN 2, GLU 2, HIS 2 (residue and the binding sites it lines).

Found with

  • GW2 · (2~{S})-~{N}-[(2~{S},3~{S},4~{R})-1-[(1~{S},4~{A}~{S}, 8~{A}~{R})-1,2,3,4,4~{A},5,6,7,8,8~{A}-decahydronaphthalen-1-yl]-4-methyl-3,5-bis(oxidanyl) pentan-2-yl]-3-(4-methoxyphenyl)-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide
  • MG · Magnesium ion
  • CL · Chloride ion
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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