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Ligand · GNT

GNT · (-)-galanthamine

GNT, (-)-galanthamine (C17 H21 N O3, 287.4 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
GNT
Formula
C17 H21 N O3
Class
ligand
Structures
12
PDB entries
6

Binding sites

GNT in 12 structures; the first of them:

  • 1DX6 · Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3A resolution · GNT A602 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, TYR130, GLU199 and 9 more
  • 1QTI · Acetylcholinesterase (E.C.3.1.1.7) · GNT A600 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, SER122, TYR130 and 10 more
  • 1W6R · Complex of TcAChE with galanthamine derivative · GNT A1536 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, TYR130, GLU199 and 9 more
  • 1W76 · Orthorhombic form of Torpedo californica acetylcholinesterase (AChE) complexed with… · GNT A1538 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, GLU199, SER200 and 5 more
  • 2PH9 · Galanthamine bound to an ACh-binding Protein · GNT A301 · binds TYR93, TRP147, GLN186, TYR188, TYR195, SER167
  • 4EY6 · Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with… · GNT A604 · binds ASP74, TRP86, GLY120, GLY121, GLY122, TYR124, SER125, TYR133 and 9 more
  • 1DX6 · Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3A resolution · GNT A602 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, TYR130, GLU199 and 9 more
  • 1QTI · Acetylcholinesterase (E.C.3.1.1.7) · GNT A600 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, SER122, TYR130 and 10 more
  • 1W6R · Complex of tcache with galanthamine derivative · GNT A1536 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, TYR130, GLU199 and 9 more
  • 1W76 · Orthorhombic form of torpedo californica acetylcholinesterase (ache) complexed with… · GNT A1538 · binds ASP72, TRP84, GLY117, GLY118, GLY119, TYR121, GLU199, SER200 and 5 more
  • 2PH9 · Galanthamine bound to an ach-binding protein · GNT A301 · binds TYR93, TRP147, GLN186, TYR188, TYR195, SER167
  • 4EY6 · Crystal structure of recombinant human acetylcholinesterase in complex with… · GNT A604 · binds ASP74, TRP86, GLY120, GLY121, GLY122, TYR124, SER125, TYR133 and 9 more

Residues it binds most

TYR 22, GLY 14, PHE 14, TRP 22, SER 20, ASP 14, GLU 14, HIS 14, CYS 4, GLN 6 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • PG4 · Tetraethylene glycol
  • MG · Magnesium ion
  • FUC · alpha-L-fucopyranose
  • NO3 · Nitrate ion
  • EDO · 1,2-ethanediol
  • PE8 · 3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol

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