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Ligand · GMR

GMR · 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-car boxamide

GMR, 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-car boxamide (C24 H34 N4 O5 S, 490.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
GMR
Formula
C24 H34 N4 O5 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

GMR in 2 structures; the first of them:

  • 4YVX · Crystal structure of AKR1C3 complexed with glimepiride · GMR A401 · binds TYR24, LEU54, TYR55, TRP86, HIS117, SER118, LEU122, LEU128 and 9 more
  • 4YVX · Crystal structure of AKR1C3 complexed with glimepiride · GMR A401 · binds TYR24, LEU54, TYR55, TRP86, HIS117, SER118, LEU122, LEU128 and 9 more

Residues it binds most

LEU 4, SER 4, TYR 4, TRP 4, PHE 4, ASN 4, HIS 4, VAL 4, MET 2 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate

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