GKA · (2r,6s,12z,13as,14ar,16as)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl) oxy]-N-[(1-methylcyclopropyl)sulfonyl]-5,16-dioxo-1,2, 3,6,7,8,9,10,11,13A,14,15,16,16A-tetradecahydrocyclopropa[e]pyrrolo[1,2-A][1, 4]diazacyclopentadecine-14A(5H)-carboxamide

Binding sites

GKA in 4 structures; the first of them:

• 6DIR · Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67) · GKA A1201 · binds GLN1041, THR1042, PHE1043, TYR1056, HIS1057, GLY1058, VAL1078, ASP1081 and 14 more
• 6DIV · Crystal structure of HCV NS3/4A D168A protease in complex with P4-P5-2 (AJ-67) · GKA A1201 · binds GLN1041, THR1042, PHE1043, TYR1056, HIS1057, GLY1058, VAL1078, ASP1081 and 13 more
• 6DIR · Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (aj- 67) · GKA A1201 · binds GLN1041, THR1042, PHE1043, TYR1056, HIS1057, GLY1058, VAL1078, ASP1081 and 14 more
• 6DIV · Crystal structure of HCV NS3/4A D168A protease in complex with P4-P5-2 (aj-67) · GKA A1201 · binds GLN1041, THR1042, PHE1043, TYR1056, HIS1057, GLY1058, VAL1078, ASP1081 and 12 more

Residues it binds most

SER 4, ALA 4, ARG 4, GLY 4, PHE 4, VAL 4, ASP 4, GLN 4, HIS 4, ILE 4 (residue and the binding sites it lines).

Found with

• ZN · Zinc ion
• SO4 · Sulfate ion
• GOL · Glycerol