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Ligand · GF4

GF4 · 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one

GF4, 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one (C7 H10 N6 O, 194.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues…

Component
GF4
Formula
C7 H10 N6 O
Class
ligand
Structures
4
PDB entries
2

Binding sites

GF4 in 4 structures; the first of them:

  • 3G2Y · CTX-M-9 class A beta-lactamase complexed with compound 1 (GF4) · GF4 A1 · binds SER70, ASN104, TYR105, SER130, ASN132, LYS234, THR235, GLY236 and 2 more
  • 3GR2 · AmpC beta-lactamase in complex with Fragment-based Inhibitor · GF4 A1 · binds ASN152, HIS210, VAL211, SER212, TYR221, ALA318, THR319, GLY320
  • 3G2Y · Ctx-M-9 class a beta-lactamase complexed with compound 1 (GF4) · GF4 A1 · binds SER70, ASN104, TYR105, SER130, ASN132, LYS234, THR235, GLY236 and 2 more
  • 3GR2 · Ampc beta-lactamase in complex with fragment-based inhibitor · GF4 A1 · binds ASN152, HIS210, VAL211, SER212, TYR221, ALA318, THR319, GLY320

Residues it binds most

SER 6, ASN 6, GLY 6, THR 6, TYR 6, LYS 4, ALA 2, HIS 2, VAL 2 (residue and the binding sites it lines).

Found with

  • DMS · Dimethyl sulfoxide

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